Five weeks of the 2021 high school football season are in the books. Here are the updated region standings heading into Week 6’s action:
Region 6-1A
| Reg. | Over. |
| McKenzie | 2-0 | 5-0 |
| Dresden | 2-0 | 4-1 |
| McEwen | 1-0 | 4-0 |
| Gleason | 1-1 | 3-2 |
| S. Fulton | 0-1 | 2-3 |
| Bruceton | 0-1 | 0-3 |
| Perry Co. | 0-1 | 0-4 |
Region 7-1A
| Reg. | Over. |
| West Carroll | 2-0 | 5-0 |
| Peabody | 1-0 | 4-0 |
| Lake Co. | 1-0 | 1-1 |
| Greenfield | 1-1 | 2-2 |
| Humboldt | 0-2 | 1-3 |
| Halls | 0-2 | 0-5 |
Region 6-2A
| Reg. | Over. |
| Lewis Co. | 2-0 | 4-1 |
| Riverside | 2-0 | 4-1 |
| E. Hickman | 1-1 | 3-1 |
| Adamsville | 1-1 | 2-3 |
| Hickman Co. | 0-2 | 2-3 |
| Scotts Hill | 0-2 | 1-4 |
Region 7-2A
| Reg. | Over. |
| Huntingdon | 2-0 | 4-1 |
| Union City | 2-0 | 4-1 |
| Westview | 2-0 | 4-1 |
| Camden | 0-1 | 1-3 |
| Gibson Co. | 0-2 | 0-4 |
| Houston Co. | 0-2 | 0-5 |
Region 7-3A
| Reg. | Over. |
| Covington | 2-0 | 5-0 |
| Dyersburg | 2-0 | 5-0 |
| Millington | 1-0 | 2-2 |
| Ripley | 1-1 | 3-2 |
| Bolton | 0-1 | 2-1 |
| Bolivar | 0-2 | 0-4 |
Region 6-4A
| Reg. | Over. |
| Hardin Co. | 2-0 | 5-0 |
| Lexington | 2-0 | 2-3 |
| Chester Co. | 1-1 | 2-3 |
| South Side | 1-1 | 1-4 |
| Liberty | 0-2 | 1-3 |
| McNairy | 0-2 | 0-5 |
Region 7-4A
| Reg. | Over. |
| Haywood | 2-0 | 4-0 |
| North Side | 2-0 | 3-2 |
| S. Gibson | 1-1 | 4-1 |
| Obion Co. | 1-1 | 3-2 |
| Milan | 0-2 | 1-3 |
| Crockett Co. | 0-2 | 1-4 |
Division II-A West
| Reg. | Over. |
| USJ | 2-0 | 3-2 |
| Jackson Chr. | 1-0 | 4-1 |
| Tipton-Rose, | 1-0 | 3-1 |
| FACS | 1-1 | 2-2 |
| Fayette Aca. | 1-1 | 1-4 |
| Harding Aca. | 0-0 | 1-1 |
| TCA | 0-0 | 0-4 |
